Trimethoprim and Sulfamethoxazole have a bit of a sordid history. Trimethoprim is a mighty warrior on her own. She can poison most Lords’ ability to generate tetrahydrofolate, a critical precursor of their very DNA, killing them from the inside out. She is effective against Haemophilus influenza, Escherichia coli, and Klebsiella pneumonia legions, to name a few.
Almost 50 years ago, the Apothecary strategists teamed her up with Sulfamethoxazole, a massive warrior who charges ahead of Trimethoprim. He also targeted the Lords’ natural tetrahydrofolate production, taking out a fraction of the evil armies to reduce the kill burden on Trimethoprim.
The two warriors battled together for more than 10 years before the Army decided the partnership was no more effective than Trimethoprim on her own. Furthermore, Sulfamethoxazole is not the gentlest protector of Soma. He irritates the outflow from the Kidney and Bladder Cities and generally affecting the flow of world’s rivers and streams. He is also a prankster, tricking the Nodal Sentry into fighting battles against imaginary opponents, and poisoning the food served in the mess halls of the Nodal Sentry barracks. As a result, the Apothecary strategists dissolved the relationship nearly 20 years ago, allowing Trimethoprim to battle alone once again.
But now, as the Lords of Pestilence evolve to evade numerous styles of Apothecary attacks, the Army is reconsidering the pairing. Together, they have the ability to take down the dreaded MRSA legions, and for that reason alone, they are quickly become known as one of the greatest Apothecary duos.